What Is the Optimum Duration of Tamoxifen Adjuvant Therapy?

Finally, there are fascinating biologic reasons to address this issue further. In essence, our understanding of the mechanism of action of tamoxifen and other hormonal agents is changing. Initial theories suggested these agent were cytostatic and essentially acted by "freezing" cells in the early G1 phase of the cell cycle. Thus, it was logical to hypothesize that it may be necessary to administer adjuvant tamoxifen indefinitely to keep the breast cancer cell frozen in the early G 1 phase to prevent tumor